For U.S. Healthcare Professionals Only
For U.S. Healthcare Professionals Only
SCHEDULE A PROGRAM
MSL PORTAL

CASCADE RESOURCES

CASCADE PROGRAMS
RESOURCES

Search Content

Resource Categories
Resource Categories

What is Cortisol

An overview of cortisol’s role in normal physiology, its circadian rhythm, and its regulation by the HPA axis. Shows how cortisol impacts metabolism, immune response, blood pressure, and overall homeostasis.
Preview
Resources:

What is Cortisol

Download

Understanding Cortisol – Glucocorticold Receptor Signaling

Explains the cellular and molecular biology of cortisol signaling and cortisol bioavailability. Includes glucocorticoid receptor binding and activity, enzymes such as 11β-HSD, and what these mean for cortisol testing and disease patterns.
Preview
Resources:

Understanding Cortisol – Glucocorticold Receptor Signaling

Download

What Causes Hypercortisolism?

Covers the main causes of hypercortisolism including pituitary, adrenal, and ectopic neoplasms, as well as physiologic cases such as depression, stress, or alcohol use. Also discusses circadian disruptions and malfunction of feedback loops that prevent proper regulation.
Preview
Resources:

What Causes Hypercortisolism?

Download

Clinical Features of Hypercortisolism

Reviews the signs and symptoms seen across mild to severe cortisol excess. Discusses how multiple organ systems are affected and how those overlapping conditions should raise suspicion.
Preview
Resources:

Clinical Features of Hypercortisolism

Download

Negative Impact of Hypercortisolism on Cardiovascular Health

Shows how cortisol drives hypertension, atherosclerosis, and clotting risk. Focuses on data linking hypercortisolism to higher cardiovascular mortality and endothelial dysfunction.
Preview
Resources:

Negative Impact of Hypercortisolism on Cardiovascular Health

Download

Metabolic Dysregulation in Hypercortisolism

Focuses on how cortisol disrupts glucose and lipid balance, which in turn causes insulin resistance and visceral fat gain. Ties chronic elevated cortisol to weight issues, dyslipidemia, and cardiometabolic risk.
Preview
Resources:

Metabolic Dysregulation in Hypercortisolism

Download